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Michael Novakhov - SharedNewsLinks℠

“Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice” | The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice – bioRxiv | Sars-cov-2 in animals | Wild rodent secondary reservoirs of sars-cov-2


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“Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice” | The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice – bioRxiv | Sars-cov-2 in animals | Wild rodent secondary reservoirs of sars-cov-2

RT @YourDailyCurse: @mikenov twitter.com/ArisKatzouraki… 

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Very interesting thread on the work from @SimonLoriereLab & coworkers on the possibility of extension of the host range of P1 & B1351 to rodents. twitter.com/SimonLoriereLa…


14 likes, 3 retweets


Retweeted by  Michael Novakhov (mikenov) on Monday, March 22nd, 2021 8:15am

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RT @SimonLoriereLab: Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteu… 

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Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteur *not peer reviewed yet*, short 🧵
biorxiv.org/cgi/content/sh… 1/9


Retweeted by  Michael Novakhov (mikenov) on Monday, March 22nd, 2021 8:27am

742 likes, 314 retweets

sars-cov-2 in rodents – Google Search google.com/search?q=sars-… npr.org/sections/goats… 

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sars-cov-2 in rats and mice – Google Search google.com/search?q=sars-… news-medical.net/news/20210308/… 

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sars-cov-2 in animals – Google Search

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SARS-CoV-2 in animals | American Veterinary Medical …

www.avma.org › sars-cov-2-animals-including-pets

<a href=”http://www.avma.org” rel=”nofollow”>www.avma.org</a> › sars-cov-2-animals-including-pets
Mar 2, 2021 — Clinical signs of SARSCoV2 infection in cats and dogs · Fever · Coughing · Difficulty breathing or shortness of breath · Lethargy · Sneezing · Nasal …

COVID-19 and Animals | CDC

www.cdc.gov › 2019-ncov › daily-life-coping › animals

<a href=”http://www.cdc.gov” rel=”nofollow”>www.cdc.gov</a> › 2019-ncov › daily-life-coping › animals
Feb 10, 2021 — Animals that can be infected with the virus that causes COVID-19 · A small number of pet cats and dogs have been reported to be infected with …

wild rodent secondary reservoirs of sars-cov-2 – Google Search

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Web results

SARS-CoV-2 infection, neuropathogenesis and transmission …

www.ncbi.nlm.nih.gov › pmc › articles › PMC7418741

<a href=”http://www.ncbi.nlm.nih.gov” rel=”nofollow”>www.ncbi.nlm.nih.gov</a> › pmc › articles › PMC7418741
by A Fagre · Cited by 11 — Dromedary camels, which are secondary reservoirs of MERS-CoV-2, had … suggesting that sustained transmission among wild deer mice is …

Abstract · ‎Results · ‎Discussion · ‎Methods
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capacity of SARS-CoV-2 VOCs to infect mice – Google Search

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The B1.351 and P.1 variants extend SARS-CoV-2 … – bioRxiv

www.biorxiv.org › content

<a href=”http://www.biorxiv.org” rel=”nofollow”>www.biorxiv.org</a> › content
3 days ago — The B1.351 and P.1 variants extend SARSCoV2 host range to mice … factors are involved in the capacity of SARSCoV2 VOCs to infect mice.

The B1.351 and P.1 variants extend SARS-CoV-2 … – bioRxiv

www.biorxiv.org › content

<a href=”http://www.biorxiv.org” rel=”nofollow”>www.biorxiv.org</a> › content
3 days ago — … although differences between viral lineages suggest that other factors are involved in the capacity of SARSCoV2 VOCs to infect mice.

Estimated transmissibility and impact of SARS-CoV-2 lineage …

science.sciencemag.org › 2021/03/03 › science.abg3055

<a href=”http://science.sciencemag.org” rel=”nofollow”>science.sciencemag.org</a> › 2021/03/03 › science.abg3055
by NG Davies · 2021 · Cited by 16 — A novel SARSCoV2 variant, VOC 202012/01 (lineage B.1.1.7), … comprises roughly 95% of new SARSCoV2 infections in England, … VOC 202012/01 appears unmatched in its ability to outcompete other SARSCoV2 lineages in England. … Adaptation of SARSCoV2 in BALB/c mice for testing vaccine …

SARS-CoV-2 variants and ending the COVID-19 pandemic …

www.thelancet.com › PIIS0140-6736(21)00370-6 › fulltext

<a href=”http://www.thelancet.com” rel=”nofollow”>www.thelancet.com</a> › PIIS0140-6736(21)00370-6 › fulltext
by A Fontanet · Cited by 11 — The COVID-19 pandemic has devastated health-care systems, shut down … to protect against infection or disease from these new SARSCoV2 variants. … to help develop expertise and capacity as well as strengthen health systems. … (AZD1222) vaccine against SARSCoV2 VOC 202012/01 (B.1.1.7).

The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice | bioRxiv

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The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice

Xavier MontagutelliMatthieu ProtLaurine LevillayerEduard Baquero SalazarGrégory JouvionLaurine ConquetFlora DonatiMélanie AlbertFabiana GambaroSylvie BehillilVincent EnoufDominique RoussetJean JaubertFelix ReySylvie van der WerfEtienne Simon-Loriere

Abstract

Receptor recognition is a major determinant of viral host range, as well as infectivity and pathogenesis. Emergences have been associated with serendipitous events of adaptation upon encounters with a novel host, and the high mutation rate of RNA viruses has been proposed to explain their frequent host shifts 1. SARS-CoV-2 extensive circulation in humans has been associated with the emergence of variants, including variants of concern (VOCs) with diverse mutations in the spike and increased transmissibility or immune escape 2. Here we show that unlike the initial virus, VOCs are able to infect common laboratory mice, replicating to high titers in the lungs. This host range expansion is explained in part by the acquisition of changes at key positions of the receptor binding domain that enable binding to the mouse angiotensin-converting enzyme 2 (ACE2) cellular receptor, although differences between viral lineages suggest that other factors are involved in the capacity of SARS-CoV-2 VOCs to infect mice. This abrogation of the species barrier raises the possibility of wild rodent secondary reservoirs and provides new experimental models to study disease pathophysiology and countermeasures.

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Michael Novakhov - SharedNewsLinks℠

RT @YourDailyCurse: @mikenov twitter.com/ArisKatzouraki…


Michael_Novakhov
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from mikenov on Twitter.

Very interesting thread on the work from @SimonLoriereLab & coworkers on the possibility of extension of the host range of P1 & B1351 to rodents. twitter.com/SimonLoriereLa…


14 likes, 3 retweets


Retweeted by

Michael Novakhov (mikenov)
on Monday, March 22nd, 2021 8:15am

1 retweet

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Michael Novakhov - SharedNewsLinks℠

RT @SimonLoriereLab: Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteu…


Michael_Novakhov
shared this story
from mikenov on Twitter.

Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteur *not peer reviewed yet*, short 🧵
biorxiv.org/cgi/content/sh… 1/9


Retweeted by

Michael Novakhov (mikenov)
on Monday, March 22nd, 2021 8:27am

742 likes, 314 retweets

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Michael Novakhov - SharedNewsLinks℠

sars-cov-2 in rodents – Google Search google.com/search?q=sars-… npr.org/sections/goats…


Michael_Novakhov
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Michael Novakhov - SharedNewsLinks℠

sars-cov-2 in rats and mice – Google Search google.com/search?q=sars-… news-medical.net/news/20210308/…


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Michael Novakhov - SharedNewsLinks℠

Putin responds to Biden calling him a killer – Google Search


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Hear Putin’s response to Biden calling him a ‘killer’ – CNN Video

www.cnn.com › video › playlists › top-news-videos

<a href=”http://www.cnn.com” rel=”nofollow”>www.cnn.com</a> › video › playlists › top-news-videos
Russian President Vladimir Putin responded to President Joe Biden comments made during an ABC News …

2 days ago

Russia reacts angrily after Biden calls Putin a ‘killer’ – CNN

www.cnn.com › 2021/03/18 › europe › biden-putin-killer…

<a href=”http://www.cnn.com” rel=”nofollow”>www.cnn.com</a> › 2021/03/18 › europe › biden-putin-killer…
2 days ago — Moscow (CNN) The Kremlin has reacted angrily to US President Joe Biden‘s remarks that Russian leader Vladimir Putin is “a killer,” calling the …

Putin responds to Biden calling him a killer: ‘Takes one to …

www.timesofisrael.com › putin-responds-to-biden-calli…

<a href=”http://www.timesofisrael.com” rel=”nofollow”>www.timesofisrael.com</a> › putin-responds-to-biden-calli…
2 days ago — Russian President Vladimir Putin on Thursday said it “takes one to know one” in response to US President Joe Biden describing him as a “killer …
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Michael Novakhov - SharedNewsLinks℠

путин ответил байдену – YouTube


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Michael Novakhov - SharedNewsLinks℠

Putin responds to Biden?s comments that he?s a killer


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Putin spokesman Dmitry Peskov also seemed to imply that they could get worse, warning Thursday that Russia’s response to Biden’s remarks will be “absolutely clear.” He didn’t elaborate.

“It’s clear that [Biden] doesn’t want to normalize relations with our country. This is what we’ll be guided by from now on,” Peskov said.

The Biden administration has imposed sanctions on Russia over the poisoning of opposition leader Alexei Navalny in August. Navalny has said Putin is responsible for nearly killing him; the Kremlin has denied it has any connection to the toxic attack. After recovering in Germany for five months, Navalny returned to Russia in January and was immediately jailed.

When asked by ABC News if he believes Putin is a killer, Biden answered, “I do.” Biden also described Putin as having no soul, adding that he would “pay a price” for allegedly meddling in the 2020 U.S. presidential election, something the Kremlin denies.

Moscow then took the unusual move of temporarily recalling its ambassador to the United States, Anatoly Antonov, in what’s believed to be the first such instance in more than 20 years.

Antonov is leaving Washington for Moscow on Saturday, the Russian embassy said, adding that his trip is “to discuss ways to rectify Russia-U.S. ties that are in crisis.”

“The current situation is a result of the deliberate policy of Washington that during the past years was making steps to bring — in essence, intentionally — our bilateral interaction into a deadlock,” the embassy said in a statement.

Peskov, the Kremlin spokesman, declined to comment when asked if diplomatic relations between the countries could be severed entirely.

In his first comments on Biden’s interview, Putin responded Thursday with a Russian schoolyard expression suggesting that Biden’s accusations revealed more about him than the Russian president. The phrase can be roughly translated as, “I know you are, but what am I?”

Speaking on a video call with residents of Crimea marking the anniversary of its 2014 annexation from Ukraine, Putin pointed to the United States’ history of killing Native Americans and slavery.

“Each nation and every state has very hard, dramatic, and bloody events in their history. But when we assess other people or even when we assess other states and other nations, we always sort of look in the mirror, and we always see ourselves there. Because we always attribute to other people that which we breathe ourselves and what we essentially are,” Putin said.

Russian government officials have reacted angrily to Biden’s remarks. Konstantin Kosachev, a deputy speaker of the Russian parliament’s upper house, said in a Facebook post that Biden’s “gross statement sends any expectations for the new U.S. administration’s policy toward Russia down the drain.”

“Recalling the Russian ambassador from Washington to Moscow for consultations is a prompt and adequate reaction, the only correct one in this situation. I suspect that it won’t be the last one if the American side doesn’t offer explanations and apologies,” he added.

Foreign Ministry spokeswoman Maria Zakharova told Russian state television on Thursday that Moscow expects an explanation for Biden’s comments.

“Why do we always have to translate their strange, unintelligible political gibberish into normal speech?” she said.

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Michael Novakhov - SharedNewsLinks℠

Biden calls Putin a ‘KILLER with no soul’ and warns of ‘price he’s going to pay’ for election interference – Tweets by ‎@mikenov


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Buyer of Jeffery Epstein’s NYC mansion is former Goldman exec


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This place is gonna need a really good cleaning.

The mystery buyer who snapped up Jeffrey Epstein’s posh Upper East Side mansion for a bargain $51 million is a former Goldman Sachs executive who is moving to New York from London and plans to live in the house with his wife.

Michael D. Daffey bought the seven-story, 40-room property at 9 E. 71st St. at far below its original $88 million asking price — and is determined to make sure not a trace of its twisted former owner remains.

“They are planning a complete makeover, physically and spiritually,” a source said.

The Australia native recently retired from the major financial firm after spending the past year as Goldman’s global markets chairman in charge of remodeling trade in Europe after Brexit — and also after making a killing in bitcoin.

“Mr. Daffey had never previously been in the home nor ever met its owner, but he is a big believer in New York’s future and will take the other side of all the people who say the city’s best days may be in the past,” said Stu Loeser, a spokesman for Daffey.

Top brokers tell The Post the price is a steal, considering that any similar Manhattan property that did not have a connection to one of America’s most twisted sex criminals could have easily fetched $100 million. 

“I think it is half off,” said top broker Dolly Lenz, who had been among those trying to sell the property. “It is 28,000 square feet. That’s less than $4,000 a foot for the most magnificent mansion on the best block, just off Fifth Avenue. It’s the very best in New York.”

Even such a deal didn’t tempt many who could afford that price range.

“We offered it to a lot of people who said, ‘We don’t want to go near that place,’” Lenz said. “Fancy international people who are always in for a deal said, ‘No way.’”

Sources say none of Epstein’s old possessions are in the house.

“The house was totally empty,” a source said. “There was no creepy weird stuff in it at all.”

Another source said Daffey bought it with cash and a bridge loan. 

Adam Modlin, of the Modlin Group, repped both Daffey and the Epstein estate as broker.

Lenz thought Daffey made a good property decision to buy.

“I think he made a smart move, however, it will be a long time before people forget it was a place were children were abused,” she said. “But he’s betting on it long-term. That’s what some people do.” 

The money is going straight to a Jeffrey Epstein victims restitution fund, which is controlled by Epstein’s estate.

 In 2019, Epstein was found dead in his prison cell awaiting trial for sex crimes in the abuse of girls as young as 14. Epstein pleaded not guilty. During an FBI raid, federal agents found child sex abuse images in the mansion’s safe. The 40-room home is one of the city’s biggest.

Epstein and his alleged partner, Ghislaine Maxwell, infamously entertained the rich, royal and powerful at the home, which was wired to secretly record its guests.

Some who stayed overnight included Britain’s Prince Andrew. The mansion was previously owned by an Epstein client, Victoria’s Secret owner Les Wexner.

The sale was halted by an asset freeze request made last month in the US Virgin Islands by more than two dozen alleged victims and Denise George, the attorney general of the US Virgin Islands, after the Epstein victims compensation program said it would halt compensation offers over funding concerns.

A judge overruled the request. The fund has so far received more than 150 applications from alleged victims since it launched last June, paying out $55 million so far to an undisclosed number of victims, according to reports. 

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