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“Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice” | The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice – bioRxiv | Sars-cov-2 in animals | Wild rodent secondary reservoirs of sars-cov-2

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“Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice” | The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice – bioRxiv | Sars-cov-2 in animals | Wild rodent secondary reservoirs of sars-cov-2

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RT @YourDailyCurse: @mikenov twitter.com/ArisKatzouraki… 

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Very interesting thread on the work from @SimonLoriereLab & coworkers on the possibility of extension of the host range of P1 & B1351 to rodents. twitter.com/SimonLoriereLa…


14 likes, 3 retweets


Retweeted by  Michael Novakhov (mikenov) on Monday, March 22nd, 2021 8:15am

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RT @SimonLoriereLab: Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteu… 

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Our new preprint where we show that SARS-CoV-2 VOCs are able to infect mice is out. Collaborative work @institutpasteur *not peer reviewed yet*, short 🧵
biorxiv.org/cgi/content/sh… 1/9


Retweeted by  Michael Novakhov (mikenov) on Monday, March 22nd, 2021 8:27am

742 likes, 314 retweets

sars-cov-2 in rodents – Google Search google.com/search?q=sars-… npr.org/sections/goats… 

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sars-cov-2 in rats and mice – Google Search google.com/search?q=sars-… news-medical.net/news/20210308/… 

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sars-cov-2 in animals – Google Search

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SARS-CoV-2 in animals | American Veterinary Medical …

www.avma.org › sars-cov-2-animals-including-pets

<a href=”http://www.avma.org” rel=”nofollow”>www.avma.org</a> › sars-cov-2-animals-including-pets
Mar 2, 2021 — Clinical signs of SARSCoV2 infection in cats and dogs · Fever · Coughing · Difficulty breathing or shortness of breath · Lethargy · Sneezing · Nasal …

COVID-19 and Animals | CDC

www.cdc.gov › 2019-ncov › daily-life-coping › animals

<a href=”http://www.cdc.gov” rel=”nofollow”>www.cdc.gov</a> › 2019-ncov › daily-life-coping › animals
Feb 10, 2021 — Animals that can be infected with the virus that causes COVID-19 · A small number of pet cats and dogs have been reported to be infected with …

wild rodent secondary reservoirs of sars-cov-2 – Google Search

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Web results

SARS-CoV-2 infection, neuropathogenesis and transmission …

www.ncbi.nlm.nih.gov › pmc › articles › PMC7418741

<a href=”http://www.ncbi.nlm.nih.gov” rel=”nofollow”>www.ncbi.nlm.nih.gov</a> › pmc › articles › PMC7418741
by A Fagre · Cited by 11 — Dromedary camels, which are secondary reservoirs of MERS-CoV-2, had … suggesting that sustained transmission among wild deer mice is …

Abstract · ‎Results · ‎Discussion · ‎Methods
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capacity of SARS-CoV-2 VOCs to infect mice – Google Search

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The B1.351 and P.1 variants extend SARS-CoV-2 … – bioRxiv

www.biorxiv.org › content

<a href=”http://www.biorxiv.org” rel=”nofollow”>www.biorxiv.org</a> › content
3 days ago — The B1.351 and P.1 variants extend SARSCoV2 host range to mice … factors are involved in the capacity of SARSCoV2 VOCs to infect mice.

The B1.351 and P.1 variants extend SARS-CoV-2 … – bioRxiv

www.biorxiv.org › content

<a href=”http://www.biorxiv.org” rel=”nofollow”>www.biorxiv.org</a> › content
3 days ago — … although differences between viral lineages suggest that other factors are involved in the capacity of SARSCoV2 VOCs to infect mice.

Estimated transmissibility and impact of SARS-CoV-2 lineage …

science.sciencemag.org › 2021/03/03 › science.abg3055

<a href=”http://science.sciencemag.org” rel=”nofollow”>science.sciencemag.org</a> › 2021/03/03 › science.abg3055
by NG Davies · 2021 · Cited by 16 — A novel SARSCoV2 variant, VOC 202012/01 (lineage B.1.1.7), … comprises roughly 95% of new SARSCoV2 infections in England, … VOC 202012/01 appears unmatched in its ability to outcompete other SARSCoV2 lineages in England. … Adaptation of SARSCoV2 in BALB/c mice for testing vaccine …

SARS-CoV-2 variants and ending the COVID-19 pandemic …

www.thelancet.com › PIIS0140-6736(21)00370-6 › fulltext

<a href=”http://www.thelancet.com” rel=”nofollow”>www.thelancet.com</a> › PIIS0140-6736(21)00370-6 › fulltext
by A Fontanet · Cited by 11 — The COVID-19 pandemic has devastated health-care systems, shut down … to protect against infection or disease from these new SARSCoV2 variants. … to help develop expertise and capacity as well as strengthen health systems. … (AZD1222) vaccine against SARSCoV2 VOC 202012/01 (B.1.1.7).

The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice | bioRxiv

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The B1.351 and P.1 variants extend SARS-CoV-2 host range to mice

Xavier MontagutelliMatthieu ProtLaurine LevillayerEduard Baquero SalazarGrégory JouvionLaurine ConquetFlora DonatiMélanie AlbertFabiana GambaroSylvie BehillilVincent EnoufDominique RoussetJean JaubertFelix ReySylvie van der WerfEtienne Simon-Loriere

Abstract

Receptor recognition is a major determinant of viral host range, as well as infectivity and pathogenesis. Emergences have been associated with serendipitous events of adaptation upon encounters with a novel host, and the high mutation rate of RNA viruses has been proposed to explain their frequent host shifts 1. SARS-CoV-2 extensive circulation in humans has been associated with the emergence of variants, including variants of concern (VOCs) with diverse mutations in the spike and increased transmissibility or immune escape 2. Here we show that unlike the initial virus, VOCs are able to infect common laboratory mice, replicating to high titers in the lungs. This host range expansion is explained in part by the acquisition of changes at key positions of the receptor binding domain that enable binding to the mouse angiotensin-converting enzyme 2 (ACE2) cellular receptor, although differences between viral lineages suggest that other factors are involved in the capacity of SARS-CoV-2 VOCs to infect mice. This abrogation of the species barrier raises the possibility of wild rodent secondary reservoirs and provides new experimental models to study disease pathophysiology and countermeasures.


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